反应 #1876837

反应方程式

dichloromethane

aniline

para-toluoyl chloride

→

Para-methylbenzanilide

溶剂

ether

反应条件

后处理

1. 1
   过滤filtered immediately
2. 2
   洗涤The filtrate was washed with 1 M HCl (2×50 mL), 0.1 M NaOH (2×50 mL), and saturated aqueous ammonium chloride
3. 3
   干燥dried over Na2SO4
4. 4
   浓缩concentrated

实验过程

To a 0° C. dichloromethane (300 mL) solution of 25 mL (274 mmol) of aniline was added 16 mL (123 mmol) para-toluoyl chloride over 10 min. The mixture was stirred at room temperature for 0.5 h, treated with 200 mL of ether and filtered immediately. The filtrate was washed with 1 M HCl (2×50 mL), 0.1 M NaOH (2×50 mL), and saturated aqueous ammonium chloride, dried over Na2SO4 and concentrated. Para-methylbenzanilide (17.3 g) was obtained as a tan solid and used directly.

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