反应 #1876834

反应方程式

4-fluorophenyl methyl sulfone

3-aminopyrrolidine

potassium carbonate

→

4-(pyrrolidin-3-ylamino)phenyl methyl sulfone

收率 102.6%

溶剂

DMF

反应条件

后处理

1. 1
   温度Upon cooling to room temperature
2. 2
   其他the mixture was partitioned between EtOAc and water
3. 3
   干燥dried over MgSO4
4. 4
   浓缩concentrated

实验过程

To 500 mg (2.87 mmol) 4-fluorophenyl methyl sulfone dissolved in 4 mL DMF was added 247 mg (2.87 mmol) 3-aminopyrrolidine followed by 793 mg (5.74 mmol) potassium carbonate. The mixture was heated to 70° C. and stirred for 48 h. Upon cooling to room temperature, the mixture was partitioned between EtOAc and water, dried over MgSO4 and concentrated to provide 708 mg of 4-(pyrrolidin-3-ylamino)phenyl methyl sulfone, pure by 1H NMR.

来源