反应 #1876833

反应方程式

4-(methylthio)aniline

triethylamine

4-fluorobenzyl bromide

→

4-[(4-fluorobenzyl)amino]thioanisole

收率 31.2%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他partitioned between dichloromethane and sat. aqueous ammonium chloride
2. 2
   干燥dried over MgSO4
3. 3
   浓缩concentrated
4. 4
   其他Purification by column chromatography
5. 5
   洗涤eluting with ethyl acetate/hexane

实验过程

To 5.0 mL (40.19 mmol) of 4-(methylthio)aniline and 8.4 mL (60.28 mmol) triethylamine dissloved in 30 mL dichloromethane was added 5.0 mL (40.19 mmol) 4-fluorobenzyl bromide. The mixture was stirred at room temperature for 12 h, partitioned between dichloromethane and sat. aqueous ammonium chloride, dried over MgSO4 and concentrated. Purification by column chromatography, eluting with ethyl acetate/hexane, provided 3.10 g of 4-[(4-fluorobenzyl)amino]thioanisole, along with recovered starting material.

来源