反应 #1876815

反应方程式

Boron tribromide

Compound ( e )

4-ethoxy-2-trifluoromethylphenol

→

Compound ( g )

收率 63.2%

2-trifluoromethylhydroquinone

收率 63.2%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   workup.ADDITIONwas slowly added dropwise at the same temperature
2. 2
   萃取the aqueous layer was extracted with ether
3. 3
   洗涤washed with saturated aqueous sodium chloride
4. 4
   干燥dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

实验过程

Boron tribromide (11.8 g) was slowly added dropwise to dichloromethane (41 mL) cooled to −78° C., and then Compound (e) (6.47 g) dissolved in dichloromethane (60 mL) was slowly added dropwise at the same temperature and the mixture was stirred at room temperature for 2 hours. The reaction mixture was then poured into ice water and the aqueous layer was extracted with ether. The organic layers were combined, washed with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 3.53 g of Compound (g).

来源