反应 #1876812

反应方程式

Bromine

Compound ( b )

3-ethoxybenzotrifluoride

Water

→

Compound ( c )

收率 76.9%

2-bromo-5-ethoxybenzotrifluoride

收率 76.9%

溶剂

ether

反应条件

后处理

1. 1
   萃取the aqueous layer was extracted three times with ether
2. 2
   洗涤washed with saturated aqueous sodium bicarbonate and water
3. 3
   干燥dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

实验过程

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

来源