反应 #1869218

反应方程式

Water

Salicylaldehyde

(2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate

Cs2CO3

→

subtitle compound

收率 114.8%

2-[(2S)-oxiran-2-ylmethoxy]benzaldehyde

收率 114.8%

溶剂

DMF

反应条件

后处理

1. 1
   萃取the mixture was extracted with DCM (2×50 ml)
2. 2
   洗涤The combined organic extracts were washed with water (2×50 ml)
3. 3
   其他The volatiles were removed in vacuo

实验过程

Salicylaldehyde (486 mg, 3.99 mmol) and (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (900 mg, 3.47 mmol) was dissolved in DMF (5 ml) and Cs2CO3 (1.28 g, 3.94 mmol) was added. The reaction mixture stirred for 12 at room temperature. Water (100 ml) was added, and the mixture was extracted with DCM (2×50 ml). The combined organic extracts were washed with water (2×50 ml). The volatiles were removed in vacuo to give the subtitle compound (76%, 710 mg), which was used directly in the next step.

来源