反应 #1869217

反应方程式

AlCl3

4-tert-butyl-2-methoxybenzenesulfonyl chloride

pyrrolidine

→

subtitle compound

收率 53.3%

2-(pyrrolidin-1-ylsulfonyl)phenol

收率 53.3%

溶剂

xylene

DMF

反应条件

后处理

1. 1
   浓缩concentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in xylene (10 ml)
3. 3
   workup.STIRRINGThe resulting mixture was stirred for 18 h at 70° C
4. 4
   workup.ADDITIONwas poured
5. 5
   workup.STIRRINGinto stirred ice-cold water
6. 6
   萃取extracted with ether (2×30 ml)
7. 7
   干燥The ether layer was dried over sodium sulfate
8. 8
   过滤filtered
9. 9
   浓缩concentrated

实验过程

To a solution of 4-tert-butyl-2-methoxybenzenesulfonyl chloride (258 mg, 0.99 mmol) in DMF (6 ml) was added pyrrolidine (70 mg, 0.99 mmol) and the solution was stirred at ambient temperature for 30 minutes, and concentrated in vacuo. The residue was dissolved in xylene (10 ml) and then added to mixture of AlCl3 (525 mg, 3.39 mmol) in xylene (5 ml). The resulting mixture was stirred for 18 h at 70° C. After colling the mixture was poured into stirred ice-cold water, and extracted with ether (2×30 ml). The ether layer was dried over sodium sulfate, filtered and concentrated to give 120 mg of subtitle compound.

来源