反应 #1869209

反应方程式

(2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate

(3S)-1-[(2-hydroxyphenyl)acetyl]pyrrolidin-3-ol

Cs2CO3

→

subtitled compound

收率 14.3%

(3S)-1-({2-[(2S)-Oxiran-2-ylmethoxy]phenyl}acetyl)pyrrolidin-3-ol

收率 14.3%

溶剂

DMF

反应条件

后处理

1. 1
   其他The reaction mixture was partitioned between ethyl acetate and H2O
2. 2
   干燥The organic layer was dried over Na2SO4
3. 3
   过滤filtered
4. 4
   浓缩concentrated
5. 5
   其他The residue was purified by silica gel flash chromatography/(0-3% methanol in dichloromethane)

实验过程

A mixture of (2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate (228 mg, 0.88 mmol), (3S)-1-[(2-hydroxyphenyl)acetyl]pyrrolidin-3-ol (196 mg, 0.88 mmol) and Cs2CO3 (344 mg, 1.05 mmol) in DMF (5 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography/(0-3% methanol in dichloromethane) to give the subtitled compound (35 mg).

来源