反应 #1869208

反应方程式

(3S)-pyrrolidin-3-ol

(2-hydroxyphenyl)acetic acid

→

subtitled compound

收率 46.3%

(3S)-1-[(2-Hydroxyphenyl)acetyl]pyrrolidin-3-ol

收率 46.3%

溶剂

DMF

DMF

反应条件

后处理

1. 1
   workup.STIRRINGthe reaction mixture was stirred at room temperature overnight
2. 2
   其他The reaction mixture was partitioned between ethyl acetate and H2O
3. 3
   干燥The organic layer was dried over Na2SO4
4. 4
   过滤filtered
5. 5
   浓缩concentrated
6. 6
   其他The residue was purified by silica gel flash chromatography (0-3% methanol in dichloromethane)

实验过程

A mixture of (2-hydroxyphenyl)acetic acid (304 mg, 2.0 mmol) and N,N′-carbonyldiimidazole (405 mg, 2.5 mmol) in DMF (5 nL) was stirred at room temperature for 45 min. A solution of (3S)-pyrrolidin-3-ol (435 mg, 5.0 mmol) in DMF (1.5 mL) was added and the reaction mixture was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-3% methanol in dichloromethane) to give the subtitled compound (205 mg).

来源