反应 #1869207

反应方程式

2-(2-hydroxyphenyl)-N-methylacetamide

(2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate

cesium carbonate

→

subtitle compound

收率 28.9%

N-Methyl-2-{2-[(2S)-oxiran-2-ylmethoxy]phenyl}acetamide

收率 28.9%

溶剂

1-methylpyrrolidin-2-one

water

反应条件

后处理

1. 1
   其他prepared
2. 2
   萃取extracted with ethyl acetate
3. 3
   干燥the combined organic layers were dried with sodium sulphate, volatiles
4. 4
   其他were removed in vacuo
5. 5
   其他The residue was purified by recrystillaziation from ethyl acetate/heptane

实验过程

A mixture of 2-(2-hydroxyphenyl)-N-methylacetamide (1.00 g, 6.1 mmol) prepared according to a known procedure (Bernd, Peschke, Eur. J. Med. Chem., 2000, 35, 599-618), (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (1.58 g, 6.1 mmol) and cesium carbonate (2.37 g, 7.3 mmol) in 1-methylpyrrolidin-2-one (15 ml) was stirred at room temperature overnight. The mixture was diluted with water and extracted with ethyl acetate, the combined organic layers were dried with sodium sulphate, volatiles were removed in vacuo. The residue was purified by recrystillaziation from ethyl acetate/heptane; (390 mg) of the subtitle compound was obtained.

来源