反应 #1869206

反应方程式

(2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate

2-methoxyphenol

Cs2CO3

→

subtitled compound

收率 85.3%

(2S)-2-[(2-Methoxyphenoxy)]oxirane

收率 85.3%

溶剂

DMF

反应条件

后处理

1. 1
   其他The reaction mixture was partitioned between ethyl acetate and H2O
2. 2
   干燥The organic layer was dried over Na2SO4
3. 3
   过滤filtered
4. 4
   浓缩concentrated
5. 5
   其他The residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum spirit 40-60)

实验过程

A mixture of (2S)-oxiran-2-ylmethyl-3-nitrobenzenesulfonate (777 mg, 3.0 mmol), 2-methoxyphenol (372.5 mg, 3.0 mmol) and Cs2CO3 (1.3 g, 4.0 mmol) in DMF was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum spirit 40-60) to give subtitled compound (425 mg).

来源