反应 #1869204

反应方程式

malononitrile

ammonium acetate

acetic acid

ethyl 2-(isobutyryl)acetate

→

ethyl 4,4-di-cyano-3-isopropylbut-3-enoate

溶剂

water

toluene

反应条件

后处理

1. 1
   其他for 1 hour

实验过程

1.2 30 g of malononitrile, 3.3 g of ammonium acetate and 4 ml of acetic acid are added to a solution of 55 g of ethyl 2-(isobutyryl)acetate (“AA”) in 210 ml of toluene, and the mixture is boiled at 130° for 1 hour on a water separator. Conventional work-up gives 41.0 g of ethyl 4,4-di-cyano-3-isopropylbut-3-enoate (“AB”), boiling point 95-99° at 0.4 mbar.

来源