反应 #1869203

反应方程式

cis-4-tert-Butoxycarbonylamino-3-hydroxy-piperidine-1-carboxylic acid benzyl ester

→

white solid

收率 100.5%

cis-(3-Hydroxy-piperidin-4-yl)-carbamic acid tert-butyl ester

收率 100.5%

溶剂

methanol

反应条件

后处理

1. 1
   其他was degassed
2. 2
   workup.ADDITIONPearlman's catalyst (palladium hydroxide on carbon, 20wt % Pd (dry basis), ≦50% water, 500 mg) was added
3. 3
   其他the mixture was purged with hydrogen
4. 4
   其他The mixture was degassed with argon
5. 5
   过滤filtered through a pad of Celite
6. 6
   其他evaporated to dryness

实验过程

10.0 g of cis-4-tert-Butoxycarbonylamino-3-hydroxy-piperidine-1-carboxylic acid benzyl ester slow running Isomer 2 (10b), was dissolved in methanol (350 mL) and was degassed. Pearlman's catalyst (palladium hydroxide on carbon, 20wt % Pd (dry basis), ≦50% water, 500 mg) was added and the mixture was purged with hydrogen and stirring continued under a balloon of hydrogen for 12 hours. The mixture was degassed with argon, filtered through a pad of Celite, and evaporated to dryness to afford 6.2 g (100%) of a white solid.

来源