反应 #1869200

反应方程式

5-benzyloxy-2-hydroxymethyl-4-pyrone

Kojic acid

ammonia

Erol

→

5-Benzyloxy-2-hydroxymethyl-1 H-pyridin-4-one

溶剂

ethanol

反应条件

后处理

1. 1
   温度to reflux overnight
2. 2
   过滤then filtered
3. 3
   洗涤The resultant solid was washed with ether
4. 4
   其他dried in vacuo (5.9 g)

实验过程

A mixture of 5-benzyloxy-2-hydroxymethyl-4-pyrone (prepared from Kojic acid by the method of D. Erol, J. Med. Chem., 1994, 29, 893) (9.7 g, 40 mmol), concentrated aqueous (880) ammonia (100 mL), and ethanol (20 mL) was heated to reflux overnight. The mixture was allowed to cool to room temperature then filtered. The resultant solid was washed with ether and dried in vacuo (5.9 g).

来源