反应 #1869192

反应方程式

hydroxypyridine

2-Bromo-5-hydroxy-6-nitropyridine

potassium carbonate

Et2O

→

material

收率 89.0%

Ethyl (6-bromo-2-nitro-pyridin-3-yloxy)acetate

收率 89.0%

溶剂

acetone

反应条件

后处理

1. 1
   温度The reaction was heated
2. 2
   温度at reflux for 10 hours
3. 3
   其他The precipitate was removed by suction filtration
4. 4
   浓缩the filtrate was concentrated in vacuo

实验过程

The hydroxypyridine (f) (30 g, 0.14 mol) was suspended in acetone (200 ml), and potassium carbonate (39 g, 0.28 mol) was added, followed by ethyl bromoacetate (15.7 ml, 0.14 mmol). The reaction was heated at reflux for 10 hours, then was cooled to room temperature and diluted with Et2O. The precipitate was removed by suction filtration, and the filtrate was concentrated in vacuo to afford material (38 g, 89%), which was used without further purification.

来源