反应 #1869188

反应方程式

( b )

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

phosphorous tribromide

→

product

收率 87.0%

4-Bromo-quinoline-6-carbonitrile

收率 87.0%

溶剂

—

ice water

DMF

water

反应条件

后处理

1. 1
   过滤The product was filtered off
2. 2
   洗涤washed with water and air
3. 3
   其他dried

实验过程

To a solution of (b) (12 g, 70.5 mmol) in DMF (75 ml) was added dropwise phosphorous tribromide (8 ml, 84.6 mmol) over five minutes (slightly exothermic). The reaction was allowed to cool to room temperature and was then diluted with ice water (100 ml) and stirred 1 hour then diluted with additional water (300 ml). The product was filtered off, washed with water and air dried to provide 14.3 g of product (87%).

来源