反应 #1869187

反应方程式

Intermediate ( a )

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzonitrile

Dowtherm A

→

gold

收率 94.3%

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

收率 94.3%

溶剂

ether

反应条件

后处理

1. 1
   温度After an additional five minutes at reflux
2. 2
   过滤The product was filtered off
3. 3
   洗涤thoroughly washed with ether
4. 4
   其他air dried

实验过程

Intermediate (a) (27.5 g, 0.101 mol) was slowly added over five minutes to refluxing Dowtherm A (200 ml). After an additional five minutes at reflux, the mixture was allow to cool to room temperature then ether (200 ml) was added. The product was filtered off, thoroughly washed with ether then air dried to afford the product as a gold coloured solid (16.2 g, 94%).

来源