反应 #1857544

反应方程式

Sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol

benzylbromide

→

desired compound

收率 68.9%

1-[2-benzyloxy-2-[2-chloro-4-(4-chlorophenoxy)phenyl]propyl]-1,2,4-triazole

收率 68.9%

溶剂

THF

Brine

反应条件

后处理

1. 1
   温度at reflux
2. 2
   萃取the mixture was extracted with dichloro methane (3×)
3. 3
   其他The combined organic phases were dried
4. 4
   过滤filtered through a silica plug
5. 5
   其他evaporated
6. 6
   其他The crude product was purified by column chromatography

实验过程

Sodium hydride (0.04 g) was added to a solution of 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol (0.5 g) in THF (15 mL). After 30 min benzylbromide (0.27 g) was added and the mixture was stirred for 18 h at reflux. Brine was added and the mixture was extracted with dichloro methane (3×). The combined organic phases were dried, filtered through a silica plug and evaporated. The crude product was purified by column chromatography to yield 0.43 g of the desired compound.

来源