反应 #1851973

反应方程式

p-Fluorothiophenol

β-propiolactone

sodium hydride

→

3-[(4-fluorophenyl)sulfanyl]propanoic acid

收率 89.0%

溶剂

THF

反应条件

后处理

1. 1
   workup.DISTILLATIONof freshly distilled) and
2. 2
   其他then placed in an ice bath
3. 3
   其他placed in the freezer overnight
4. 4
   其他The reaction was quenched with ice chips
5. 5
   萃取The product was extracted with ethyl acetate (1×200 mL) and dichloromethane (2×200 mL)
6. 6
   干燥dried (sodium sulfate)
7. 7
   浓缩concentrated

实验过程

p-Fluorothiophenol (5 g, 40 mmol) and β-propiolactone (2.8 g, 40 mmol) were dissolved in THF (36 mL of freshly distilled) and then placed in an ice bath. 95% sodium hydride (1 g, 42.9 mmol) was added in small portions over 1 hour. The reaction was allowed to stir at 0° C. for 2 hours, then placed in the freezer overnight. The reaction was quenched with ice chips and then acidified with concentrated hydrogen chloride until a pH of 2. The product was extracted with ethyl acetate (1×200 mL) and dichloromethane (2×200 mL), dried (sodium sulfate) and concentrated to give 3-[(4-fluorophenyl)sulfanyl]propanoic acid (7.08 g, 89%). 1H NMR (CDCl3, 300 MHz): δ 7.42-7.35 (m, 2H), 7.02 (t, 2H, J=8.6 Hz), 4.35 (t, 1H, J=6.2 Hz), 3.10 (t, 2H, J=7.3 MHz), 2.63 (t, 2H, J=7.3 Hz) ppm.

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