反应 #1841

反应方程式

phenol

potassium carbonate

5-fluoro-2-nitrotoluene

→

2-Nitro-5-phenoxytoluene

溶剂

N,N-dimethylacetamide

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture was stirred at 70°-80° C. for 30 minutes
2. 2
   温度the mixture was heated at 135°-140° C. for 2 hours
3. 3
   温度after cooling
4. 4
   浓缩concentrated in vacuo
5. 5
   workup.ADDITIONthe residue was introduced into ice
6. 6
   过滤the crystalline product was filtered off with suction
7. 7
   洗涤washed with water
8. 8
   其他dried

实验过程

14.1 g (150 mmol) of phenol were dissolved in 120 ml of anhydrous N,N-dimethylacetamide, while stirring, 20.6 g (150 mmol) of finely powdered potassium carbonate were added and the mixture was stirred at 70°-80° C. for 30 minutes. After cooling to 20° C., 23.25 g (18.3 ml, 150 mmol) of 5-fluoro-2-nitrotoluene were added dropwise, the mixture was heated at 135°-140° C. for 2 hours and, after cooling, concentrated in vacuo, the residue was introduced into ice and the crystalline product was filtered off with suction, washed with water and dried, 30 g, melting point 43°-46° C.

来源