反应 #1838

反应方程式

nitric acid

sulfuric acid

3-trifluoromethoxybenzoic acid

→

2-Nitro-5-trifluoromethoxybenzoic acid

反应条件

后处理

1. 1
   温度while cooling
2. 2
   温度The reaction mixture was heated at 50°-55° C. for 1 hour
3. 3
   温度after cooling
4. 4
   workup.ADDITIONwas poured onto ice
5. 5
   过滤the residue was filtered off with suction
6. 6
   其他to give
7. 7
   其他after drying
8. 8
   其他8.8 g of product, melting point 90°-93° C. (sintering at 85° C.)

实验过程

29.7 ml of nitric acid were added dropwise to 76.5 ml of concentrated sulfuric acid, while cooling and stirring, and 9.0 g (43.7 mmol) of 3-trifluoromethoxybenzoic acid were then added. The reaction mixture was heated at 50°-55° C. for 1 hour and, after cooling, was poured onto ice, and the residue was filtered off with suction to give, after drying, 8.8 g of product, melting point 90°-93° C. (sintering at 85° C.).

来源