反应 #1831909

反应方程式

n-octylbromide

9.7g

5-norbornene-2-methanol

Potassium hydroxide

→

4-n-octyloxymethylbicyclo[2.2.1]hept-2-ene

溶剂

DMSO

water

反应条件

后处理

1. 1
   其他A 500 mL round bottom flask equipped with a mechanical stirrer
2. 2
   其他After the above mixture was reacted at room temperature for 4 hrs
3. 3
   其他was carried out at 80° C. for 3.3
4. 4
   萃取extracted with chloroform (2×150 mL)
5. 5
   洗涤washed with water (2×100 mL)
6. 6
   干燥dried with sodium sulfate
7. 7
   其他The solvent was evaporated
8. 8
   workup.DISTILLATIONdistilled
9. 9
   其他to give pure product

实验过程

A 500 mL round bottom flask equipped with a mechanical stirrer was charged with 9.7g (0.075 mol) of 5-norbornene-2-methanol, and 25 ml of DMSO. Potassium hydroxide (7.3g, 85% in purity; 0.13 mol) was added to the above mixture. After the above mixture was reacted at room temperature for 4 hrs., 15.9 g (0.15 mol) of n-octylbromide was slowly added to the above mixture over 25 min. The reaction was carried out at 80° C. for 3.3. hrs. After the reaction mixture was cooled to room temperature, the reaction mixture was combined with water (100 mL), extracted with chloroform (2×150 mL), washed with water (2×100 mL), and dried with sodium sulfate. The solvent was evaporated and the residue was vacuum distilled to give pure product.

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