反应 #1829958

反应方程式

chloric acid

maltitol

potassium hydroxide

4-glycidyloxy benzophenone

→

1-(4-benzoylphenyl) glycerol

收率 64.9%

溶剂

dimethylsulfoxide

dimethylsulfoxide

ethyl alcohol

water

反应条件

后处理

1. 1
   其他A solution obtained
2. 2
   温度Furthermore, heating
3. 3
   workup.WAITagitation was continued for 1 hour under flow of nitrogen
4. 4
   其他purified water with the mixing ratio of 1:1, and effluent fraction in which the mixing ratio of ethyl alcohol
5. 5
   其他purified water
6. 6
   其他condensed

实验过程

Then, 2.921 g of maltitol and 476.0 mg of potassium hydroxide were dissolved in 20 ml of dimethylsulfoxide, and the mixture was stirred under flow of nitrogen for 30 minutes. A solution obtained by dissolving 719 mg of the resultant 4-glycidyloxy benzophenone dissolved in 1 ml of dimethylsulfoxide was dripped to it. Furthermore, heating and agitation was continued for 1 hour under flow of nitrogen, and the reaction system was cooled to the room temperature and neutralize with chloric acid. The reaction system was fractionated according to the column chromatography using the hyperporous polymer (Hiporous resin supplied from Mitsubishi Kasei Kogyo Kabushiki Kaisha) at first as a developing solvent with purified water, and then a mixture of ethyl alcohol and purified water with the mixing ratio of 1:1, and effluent fraction in which the mixing ratio of ethyl alcohol and purified water was 1:1 was condensed to obtained 500 mg of 1-(4-benzoylphenyl) glycerol maltitolether (Yield: 30%).

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