反应 #1827481

反应方程式

4-bromo-2-ethoxycarbonylbenzo[b]furan

sodium borohydride

ethyl acetate

methanol

→

4-bromo-2-hydroxymethylbenzofuran

收率 85.3%

溶剂

water

tetrahydrofuran

反应条件

后处理

1. 1
   其他at room temperature
2. 2
   其他the layers were separated
3. 3
   洗涤The organic layer was washed with water and brine
4. 4
   干燥dried over magnesium sulfate
5. 5
   其他evaporated

实验过程

To a solution of 4-bromo-2-ethoxycarbonylbenzo[b]furan (0.5 g) in tetrahydrofuran (5 ml) was slowly added sodium borohydride (0.21 g) at room temperature. After 5 minutes, methanol (0.5 ml) was added thereto dropwise. The reaction mixture was stirred at room temperature for one hour and then ethyl acetate and water were added thereto. The mixture was adjusted to pH 5, and the layers were separated. The organic layer was washed with water and brine, dried over magnesium sulfate and evaporated to afford 4-bromo-2-hydroxymethylbenzofuran (0.36 g).

来源