反应 #1824343

反应方程式

4-Acetoxystyrene

ammonium hydroxide

→

4-Hydroxystyrene

溶剂

THF

tetrahydrofuran

反应条件

后处理

1. 1
   洗涤Afterwards, the solution was washed three times with brine (250 ml)
2. 2
   干燥dried over anhydrous Magnesium sulfate
3. 3
   其他Solvent was removed in a rotary evaporator
4. 4
   其他the viscous liquid was dried under high vacuum for 24 hours
5. 5
   其他to give a waxy solid

实验过程

4-Acetoxystyrene (105 grams, 0.65 mole) in tetrahydrofuran (THF) (400 ml) was stirred at room temperature with 14.8 Molar ammonium hydroxide (52 ml, 0.77 mole) for 18 hours. Afterwards, the solution was washed three times with brine (250 ml) and dried over anhydrous Magnesium sulfate. Solvent was removed in a rotary evaporator and the viscous liquid was dried under high vacuum for 24 hours to give a waxy solid. Typically, this waxy solid is around 95% pure (by NMR), remainder being THF.

来源