反应 #1824339

反应方程式

sodium hydroxide

1-Chloro-3,3-dimethylbutane

magnesium

iodine crystals

diethyl ether

→

4,4-dimethyl pentanoic acid

反应条件

后处理

1. 1
   workup.ADDITIONThe mixture was poured onto dry ice (50 g) very slowly
2. 2
   其他the basic aqueous layer provided
3. 3
   萃取extracted with diethyl ether (x2)
4. 4
   萃取extracted with diethyl ether which
5. 5
   干燥was dried over magnesium sulphate
6. 6
   过滤filtered
7. 7
   其他then evaporated under vacuum

实验过程

1-Chloro-3,3-dimethylbutane (log) was added dropwise to magnesium turnings (2 g) with an initiating amount of iodine crystals in dry diethyl ether (100 ml) and Grignard formation allowed to proceed to completion over 1 hour. The mixture was poured onto dry ice (50 g) very slowly and 0.5 N sodium hydroxide added and the basic aqueous layer provided extracted with diethyl ether (x2). The basic aqueous layer was acidified and extracted with diethyl ether which was dried over magnesium sulphate, filtered then evaporated under vacuum to yield 7.2 g of 4,4-dimethyl pentanoic acid.

来源