反应 #1824326

反应方程式

product

2-(1,1-dimethylprop-2-enyl)-3-hydroxy-naphthalene-1.4-dione

methoxyamine hydrochloride

ether

→

title compound

2-(1,1-dimethylprop-2-enyl)-2-hydroxy-1-methoxyimino-naphthalene-4-one

溶剂

pyridine

反应条件

后处理

1. 1
   洗涤washed with water (2×10 ml) , 2M hydrochloric acid (2×10 ml), water (2×10 ml), saturated sodium chloride solution (10 ml)
2. 2
   干燥dried over magnesium sulphate
3. 3
   过滤Filtration and evaporation of the solvent under reduced pressure and silica gel chromatography

实验过程

A solution of the product of Example 1 (b) (250 mg, 1.03 mmol) and methoxyamine hydrochloride (95 mg, 1.14 mmol) in pyridine (5 ml) was stirred for 48 hours. The reaction mixture was dissolved in ether (50 ml) and washed with water (2×10 ml) , 2M hydrochloric acid (2×10 ml), water (2×10 ml), saturated sodium chloride solution (10 ml) and dried over magnesium sulphate. Filtration and evaporation of the solvent under reduced pressure and silica gel chromatography yielded the title compound (56 mg).

来源