反应 #1824323

反应方程式

1-(2-ethylhexyl)-2-methylbenzimidazole

2-methylbenzimidazole

2-ethylhexyl bromide

o-aminothiophenol

sulphur

→

2-(1-(2-ethylhexyl)benzimidazol-2-yl)-benzothiazole

溶剂

pyridine

反应条件

后处理

1. 1
   温度are heated for 18 hours
2. 2
   温度under reflux
3. 3
   workup.DISTILLATIONThen the pyridine is distilled off
4. 4
   workup.DISSOLUTIONthe remaining residue is dissolved
5. 5
   温度by heating in 80 g of ethanol
6. 6
   温度After cooling
7. 7
   其他are precipitated

实验过程

48.8 g (0.2 mol) of 1-(2-ethylhexyl)-2-methylbenzimidazole (prepared by the alkylation of 2-methylbenzimidazole and 2-ethylhexyl bromide under phase transfer conditions), 25 g (0.2 mol) of o-aminothiophenol and 19.2 g (0.6 mol) of sulphur in 200 ml of pyridine are heated for 18 hours under reflux. Then the pyridine is distilled off and the remaining residue is dissolved by heating in 80 g of ethanol. After cooling, 55.2 g (76% of theory) of the product, which, according to its melting point and BPLC and UV analysis, is identical to the compound obtained in Example 18 by route A, are precipitated.

来源