反应 #1824302

反应方程式

5-chloro-2, 4-dihydro-2-methyl-4-[2-[[[[1-[3(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]- 3H-1,2,4-triazol-3-one

1-[3-(trifluoromethyl)phenyl]ethanone oxime

KOH

NaH

t-butoxide

→

2,4-dihydro-5-methoxy-2-methyl-4-[2-[[[[1-[3-(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]- 3H-1,2,4-triazol-3-one

溶剂

THF

methanol

THF

反应条件

实验过程

Examples of the combined processes of Steps 2 and 3 include the reaction of 5-chloro-2, 4-dihydro-2-methyl-4-[2-[[[[1-[3(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]- 3H-1,2,4-triazol-3-one with 1-[3-(trifluoromethyl)phenyl]ethanone oxime in the presence of a base (e.g., KOH, NaH or K t-butoxide) in a suitable solvent (e.g., THF) and the subsequent reaction of the product of that reaction with methanol in the THF solution to form 2,4-dihydro-5-methoxy-2-methyl-4-[2-[[[[1-[3-(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]- 3H-1,2,4-triazol-3-one; the reaction of 5-chloro-2, 4-dihydro-2-methyl-4-[2-[[[[1-[3(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]- 3H-1,2,4-triazol-3-one with 1-[3,5-(bistrifluoromethyl)phenyl]ethanone oxime in the presence of a base and the subsequent reaction of the product of that reaction with methanol to form 5-chloro-2, 4-dihydro-2-methyl-4-[2-[[[[1-[3(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]-3H-1,2,4-triazol-3-one.

来源