反应 #1810841

反应方程式

1-Cyclobutyl-2-methyl-4-acetylimidazole

DMF

DMA

→

title compound

收率 47.0%

5-(3-Dimethylaminoprop-2-enoyl)-1-cyclobutyl-2-methylimidazole

收率 47.0%

反应条件

后处理

1. 1
   温度at reflux, under an atmosphere of nitrogen, for 54 hours
2. 2
   其他crystallised
3. 3
   过滤The solid product was collected by filtration
4. 4
   洗涤washed with DMF
5. 5
   干燥DMA and then ether and dried under vacuum at 40° C.

实验过程

1-Cyclobutyl-2-methyl-4-acetylimidazole (Method 3; 2.52 g, 14.1 mmol) was dissolved in DMF.DMA (75 mL) and the mixture heated at reflux, under an atmosphere of nitrogen, for 54 hours. The reaction mixture was allowed to cool to ambient temperature the product crystallised. The solid product was collected by filtration, washed with DMF.DMA and then ether and dried under vacuum at 40° C. to give the title compound (1.55 g, 47%) as a pale brown crystalline solid. NMR: 1.72 (m, 2H), 2.28 (m, 2H), 2.39 (s, 3H), 2.64 (m, 2H), 2.95 (m, 6H), 5.22 (m, 1H), 5.50 (d, 1H), 7.39 (s, 1H), 7.51 (d, 1H).

来源