反应 #1810816

反应方程式

thionylchloride

2-morpholin-4-yl-5-nitro-benzoic acid

→

title compound

收率 93.0%

2-Morpholin-4-yl-5-nitro-benzoyl chloride

收率 93.0%

溶剂

toluene

反应条件

后处理

1. 1
   其他The solvent was removed in vacuo
2. 2
   过滤filtered
3. 3
   其他dried

实验过程

To a suspension of 2-morpholin-4-yl-5-nitro-benzoic acid (4.0 g, 16 mmol) in toluene were added 2 drops of DMF and thionylchloride (5.7 ml, 79.3 mmol). The mixture was heated to 80° C. for 50 minutes. The solvent was removed in vacuo, and the resulting solid was stirred in ether, filtered and dried to provide the title compound (4.0 g, 93%) as a yellow solid.

来源