反应 #1810815

反应方程式

2-fluoro-5-nitrobenzoic acid

morpholine

→

title compound

收率 93.0%

2-Morpholin-4-yl-5-nitro-benzoic acid

收率 93.0%

溶剂

dioxane

反应条件

后处理

1. 1
   其他The solvent was removed in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in water
3. 3
   过滤The solid was filtered
4. 4
   洗涤washed with water
5. 5
   其他dried

实验过程

To a solution of 2-fluoro-5-nitrobenzoic acid (4.86 g, 26.2 mmol) in dioxane (50 ml) was added morpholine (11.5 ml). The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo. The residue was dissolved in water and the mixture was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide the title compound (6.2 g, 93%) as a yellow solid, MS (m/e): 251.2 (M−H, 100%).

来源