反应 #1810809

反应方程式

[4-(1,2,3-trimethyl-isothioureido)-cyclohexyl]carbamic acid benzylester

hydroiodide

chloride

EtOH

hydrazine monohydrate

→

[4-(3-Amino-1,2-dimethyl-guanidino)-cyclohexyl]-carbamic acid benzylester

hydrochloride

反应条件

后处理

1. 1
   其他A suspension obtained
2. 2
   过滤is filtered
3. 3
   其他the filtrate obtained
4. 4
   其他The mixture obtained
5. 5
   温度is refluxed for 2.5 hours and from the mixture
6. 6
   其他obtained solvent
7. 7
   其他is evaporated

实验过程

0.84 g of [4-(1,2,3-trimethyl-isothioureido)-cyclohexyl]carbamic acid benzylester in the form of a hydroiodide are stirred with 10 ml of of a strong basic ion exchanger in chloride form. A suspension obtained is filtered and the filtrate obtained is lyophilized. The lyophilisate is treated with 15 ml of EtOH and with 0.08 ml of hydrazine monohydrate. The mixture obtained is refluxed for 2.5 hours and from the mixture obtained solvent is evaporated. [4-(3-Amino-1,2-dimethyl-guanidino)-cyclohexyl]-carbamic acid benzylester in the form of a hydrochloride is obtained.

来源