反应 #1797557

反应方程式

compound B3

7-{2-[6-(4-methoxy-phenyl)-3H-imidazo[4,5-b]pyridin-2-yl]-ethyl}-azepan-2-one

Lawesson's reagent

7-{2-[6-(4-methoxy-phenyl)-3H-imidazo[4,5-b]pyridin-2-yl]-ethyl}-azepan-2-one

→

title compound

收率 83.0%

7-{2-[6-(4-Methoxy-phenyl)-3H-imidazo[4,5-b]pyridin-2-yl]-ethyl}-azepane-2-thione

收率 83.0%

反应条件

后处理

1. 1
   其他The title compound is synthesized
2. 2
   其他Purification by chromatography on flash silica gel (eluent gradient: dichloromethane/0-10 vol. % ethanol)

实验过程

The title compound is synthesized as described for 7-[2-(6-{4-cyano-phen-1-yl}-3H-imidazo[4,5-b]pyridin-2-yl)-ethyl]-azepan-2-thione (compound A2) from 120 mg of 7-{2-[6-(4-methoxy-phenyl)-3H-imidazo[4,5-b]pyridin-2-yl]-ethyl}-azepan-2-one (compound B3) and 222 mg of Lawesson's reagent. Purification by chromatography on flash silica gel (eluent gradient: dichloromethane/0-10 vol. % ethanol) affords 104 mg of the title compound as a light yellow, waxy solid. ESI-MS: 381.2 (MH+). TLC: Rf=0.64 (dichloromethane/ethanol 10:1 parts by volume).

来源