反应 #1797539

ord-a43835375065495abe8f7aaf79662902

反应方程式

O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1Cl
5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1Cl
Intermediate 3
O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1Cl
5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
OC1CCCNC1
3-hydroxypiperidine
O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1N1CCCC(O)C1
5-(3-Hydroxy-piperidin-1-y1)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

5-(3-Hydroxy-piperidin-1-y1)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide was prepared using Procedure A from 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Intermediate 3) and 3-hydroxypiperidine. Mass spectrum (ES) MH+=421.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07790711B2uspto-grants-2010_09