反应 #1797536

ord-bff61e3e7943451280be5ad56cc78ef1

反应方程式

O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1Cl
5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1Cl
Intermediate 3
O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1Cl
5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
OCC1CCCNC1
3-piperidinemethanol
O=C(NC1C2CC3CC(C2)CC1C3)c1cnn(-c2ccccc2)c1N1CCCC(CO)C1
5-(3-Hydroxymethyl-piperidin-1-y1)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

5-(3-Hydroxymethyl-piperidin-1-y1)-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide was prepared using Procedure A from 5-chloro-1-phenyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Intermediate 3) and 3-piperidinemethanol. Mass spectrum (ES) MH+=435.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07790711B2uspto-grants-2010_09