反应 #1797512

反应方程式

2-methoxy-5-chlorophenylboronic acid

4-carboxyphenylboronic acid

5-(3-bromophenyl)-1H-tetrazole

→

title compound

5-(5′-chloro-2′-methoxybiphenyl-3-yl)-1H-tetrazole

反应条件

实验过程

Following the procedure of Example 1b), except substituting 2-methoxy-5-chlorophenylboronic acid; for 4-carboxyphenylboronic acid; and substituting 5-(3-bromophenyl)-1H-tetrazole for the compound of 1a), the title compound was prepared (1.36 g; 100%) as a white solid. 1H NMR (300 MHz, d6-DMSO) δ 8.16 (s, 1H), 8.05 (d, J=7.6 Hz, 1H), 7.7 (d, J=6.6 Hz, 1H), 7.67 (t, J=7.7 Hz, 1H), 7.48 (m, 2H), 7.2 (d, J=9.1 Hz, 1H), 3.8 (s, 3H), MS (ES) m/z 287 [M+H].

来源