反应 #1797493

反应方程式

5-aminoindane

acetic anhydride

→

5-(N-acetylamino)indane

收率 84.6%

溶剂

—

ice water

acetic acid

反应条件

后处理

1. 1
   workup.ADDITIONAfter completion of the dropwise addition
2. 2
   其他After completion of the reaction
3. 3
   其他the reaction liquid
4. 4
   workup.STIRRINGwhile stirring
5. 5
   其他Crystals precipitated
6. 6
   过滤were filtered off
7. 7
   洗涤washed with 1,000 ml of water
8. 8
   其他The crystals obtained
9. 9
   其他were dried

实验过程

33.3 g (0.25 mol) of 5-aminoindane (a product of Tokyo Chemical Industry Co. Ltd.) was dissolved in 250 ml of glacial acetic acid, the resulting solution was heated to 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise thereto. After completion of the dropwise addition, the resulting solution was stirred for 4 hours. After completion of the reaction, the reaction liquid was poured in 1,500 ml of ice water while stirring. Crystals precipitated were filtered off, and washed with 1,000 ml of water. The crystals obtained were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103.5° C.)

来源