反应 #1797478

ord-49530173db4a46ca88018fc46e3407e0

反应方程式

CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
chlorpheniramine maleate
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Chlorpheniramine

溶剂

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    洗涤the product washed with USP water
  2. 2
    其他The wet cake was dried
  3. 3
    过滤sieved through a US Std #30 mesh screen

实验过程

Chlorpheniramine polistirex was prepared by mixing 3.12 kg of chlorpheniramine maleate with 26.00 kg of ion-exchange resin particles (AMBERLITE IRP69; US Std. Mesh #100-#400) suspended in USP water at about 30° C. The resulting suspension was centrifuged and the product washed with USP water. The wet cake was dried and sieved through a US Std #30 mesh screen. The chlorpheniramine content of the dried product was equivalent to approximately 11% by weight.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07790201B2uspto-grants-2010_09