反应 #1788

反应方程式

2,4-dimethyl-3-hydroxymethylpyridine

thionyl chloride

→

2,4-dimethyl-3-chloromethylpyridine

溶剂

CH2Cl2

反应条件

后处理

1. 1
   其他The solvent was removed under reduced pressure
2. 2
   其他the residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate
3. 3
   干燥The organic layer was dried with MgSO4
4. 4
   过滤filtered
5. 5
   其他the solvent removed under reduced pressure

实验过程

The 2,4-dimethyl-3-hydroxymethylpyridine (19.2 g, 140 mmol) was dissolved in CH2Cl2 (800 mL) and cooled under nitrogen to 0° C. and thionyl chloride (125 mL) was slowly added and the reaction was stirred for 18 hours. The solvent was removed under reduced pressure and the residue was partitioned between CH2Cl2 and saturated aqueous sodium bicarbonate. The organic layer was dried with MgSO4, filtered and the solvent removed under reduced pressure to give the desired 2,4-dimethyl-3-chloromethylpyridine.

来源