反应 #1787733

反应方程式

6-(2-chlorophenyl)-3-ethyl-4,5,6,7-tetrahydroindazol-4-one

aminoguanidine hydrochloride

hydrochloric acid

water

→

6-(2-chlorophenyl)-3-ethyl-4-guanidinoimino-4,5,6,7-tetrahydroindazole hydrochloride

溶剂

ethanol

反应条件

后处理

1. 1
   温度was refluxed for 4 hours
2. 2
   其他Under reduced pressure, the solvent was evaporated
3. 3
   其他The resulting crystals were recrystallized from ethanol-water

实验过程

A mixture of 6-(2-chlorophenyl)-3-ethyl-4,5,6,7-tetrahydroindazol-4-one (0.44 g), aminoguanidine hydrochloride (0.19 g), concentrated hydrochloric acid (0.24 ml), water (0.24 ml) and ethanol (40 ml) was refluxed for 4 hours. Under reduced pressure, the solvent was evaporated. The resulting crystals were recrystallized from ethanol-water to give 6-(2-chlorophenyl)-3-ethyl-4-guanidinoimino-4,5,6,7-tetrahydroindazole hydrochloride (Compound 27) (0.6 g) as colorless crystals.

来源