反应 #1784135

反应方程式

acetonitrile

4-aminothiophenol

triethylamine

1-iodoheptafluoro-n-propane

→

desired product

收率 63.2%

4-(heptafluoro-n-propylthio) aniline

收率 63.2%

溶剂

ether

反应条件

后处理

1. 1
   洗涤washed with aqueous 1N sodium hydroxide solution
2. 2
   其他purified by silica gel column chromatography

实验过程

To 20 ml of an acetonitrile solution of 1.25 g of 4-aminothiophenol and 1.11 g of triethylamine was added 5.91 g of 1-iodoheptafluoro-n-propane. The resulting mixture was stirred at room temperature for 3 hours, diluted with ether, and then washed with aqueous 1N sodium hydroxide solution, purified by silica gel column chromatography using an eluent (development solvent; hexane:ethyl acetate=4:1) to obtain 1.85 g of the desired product (Yield: 63%).

来源