反应 #1772017

反应方程式

compound 4

N-Methyl-3-pyrrolidinyl cyclopentylmandelate

ethyl bromoacetate

ethyl ether

→

Compound ( b )

3-(2-Cyclopentyl-2-phenyl-2-hydroxyacetoxy)-1-(ethoxycarbonylmethyl)-1-methylpyrrolidinium bromide

溶剂

acetonitrile

ethylene chloride

反应条件

后处理

1. 1
   其他Evaporation of acetonitrile
2. 2
   其他gave a crude product
3. 3
   其他to precipitate

实验过程

To compound 4 (0.369 g, 1.22 mmol) in 10 ml of dry acetonitrile, ethyl bromoacetate (0.377 g, 2.25 mmol) was added at room temperature. The mixture was stirred for 2 h. Evaporation of acetonitrile gave a crude product. The crude product was dissolved in a small volume of ethylene chloride and then poured into 50 ml of dry ethyl ether to precipitate. This procedure was repeated three times to obtain Compound (b) as pure product (0.45 g, 79%). White powder, m.p.: 192-194° C.

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