反应 #1755509

反应方程式

3-(β-D-glucopyranosyloxy)-4-[(4-iso-propoxyphenyl)methyl]-5-methyl-1H-pyrazole

N-(benzyloxycarbonyloxy)-succinimide

→

1-(benzyloxycarbonyl)-3-(β-D-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)methyl]-5-methylpyrazole

收率 75.3%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   温度the mixture was heated
2. 2
   温度under reflux overnight
3. 3
   浓缩The reaction mixture was concentrated under reduced pressure
4. 4
   其他the residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=10/1)

实验过程

To a solution of 3-(β-D-glucopyranosyloxy)-4-[(4-iso-propoxyphenyl)methyl]-5-methyl-1H-pyrazole (1.3 g) in tetrahydrofuran (30 mL) was added N-(benzyloxycarbonyloxy)-succinimide (1.6 g), and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=10/1) to give 1-(benzyloxycarbonyl)-3-(β-D-glucopyranosyloxy)-4-[(4-isopropoxyphenyl)methyl]-5-methylpyrazole (1.3 g).

来源