反应 #1755476

反应方程式

methyl 5-nitro-2-furoate

hydrogen

→

methyl 5-amino-2-furoate

溶剂

EtOAc

反应条件

后处理

1. 1
   过滤the mixture was filtered through a celite pad
2. 2
   浓缩concentrated

实验过程

A solution of 100 mg of methyl 5-nitro-2-furoate (Lancaster Synthesis, Windham, N.H., USA) in 20 ml of EtOAc was stirred with 20 mg of Pd/C (10%) under one atmospheric pressure of hydrogen gas. After at RT for 2 hours, the mixture was filtered through a celite pad and concentrated. Pure methyl 5-amino-2-furoate was obtained by purification on a fresh silica gel column eluted with 30% EtOAc in hexane.

来源