反应 #1755464

反应方程式

1-[2-(3,5-dimethylphenyl)-1-furan-2-yl-ethyl]-3-(2-hydroxy-ethyl)-thiourea

diisopropyethylamine

cyanomethyl trimethylphosphonium iodide

→

title compound

收率 69.1%

(4,5-Dihydro-thiazol-2-yl)-[2-(3,5-dimethyl-phenyl)-1-furan-2-yl-ethyl]-amine

收率 69.1%

溶剂

propionitrile

反应条件

实验过程

Following the procedure as described in example a solution of 1-[2-(3,5-dimethylphenyl)-1-furan-2-yl-ethyl]-3-(2-hydroxy-ethyl)-thiourea (0.46 g) and diisopropyethylamine (0.26 g) in propionitrile (20 ml) was treated with cyanomethyl trimethylphosphonium iodide (0.44 g) and heated for 16 h at a temperature of 90° C. Work-up yielded the title compound (0.30 g, 69%) as an amorphous solid.

来源