反应 #1755461

反应方程式

2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide

hydrogenchloride

→

2-(3,5-Dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethylamine

收率 77.0%

溶剂

methanol

dioxane

反应条件

后处理

1. 1
   其他The reaction mixture was quenched with aqueous potassium carbonate solution
2. 2
   萃取extracted
3. 3
   干燥the organic phases dried over magnesium sulfate
4. 4
   其他After evaporation of the solvent a yellowish oil
5. 5
   其他was obtained in 77% yield (1.05 g)

实验过程

A solution of RS 2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide (2.0 g) in methanol (12 ml) was treated with a solution of hydrogenchloride in dioxane (12 ml, 4 N) at room temperature overnight. The reaction mixture was quenched with aqueous potassium carbonate solution and adjusted to pH 8-9, extracted and the organic phases dried over magnesium sulfate. After evaporation of the solvent a yellowish oil was obtained in 77% yield (1.05 g).

来源