反应 #1747867

反应方程式

10-(4-benzyloxyphenyl)phenothiazine 5,5-dioxide

ammonium formate

→

10-(4-Hydroxyphenyl)phenothiazine 5,5-dioxide

溶剂

acetone

反应条件

后处理

1. 1
   过滤the solution was filtered
2. 2
   浓缩The filtrate was concentrated
3. 3
   workup.ADDITIONafter adding 10 ml of methanol
4. 4
   过滤The solid was filtered off with suction
5. 5
   洗涤washed with methanol
6. 6
   其他dried at 110° C. in a vacuum
7. 7
   其他drying cabinet
8. 8
   其他were obtained

实验过程

3.10 g (7.50 mmol) of 10-(4-benzyloxyphenyl)phenothiazine 5,5-dioxide, 2.30 g (35.7 mmol) of 98% ammonium formate and 7.5 g of 10% palladium on activated carbon were heated to boiling under reflux in 225 ml of acetone for 1 hour. After cooling to room temperature, the solution was filtered. The filtrate was concentrated and, after adding 10 ml of methanol, stirred overnight. The solid was filtered off with suction, washed with methanol and dried at 110° C. in a vacuum drying cabinet. 1.47 g (61% of theory) of analytically pure light gray microcrystals having an m.p. of 308-311° C. were obtained.

来源