反应 #1747866

反应方程式

4-iodophenol

benzyl chloride

potassium carbonate

→

4-Iodophenyl benzyl ether

溶剂

acetone

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度to reflux temperature
3. 3
   温度heated
4. 4
   过滤the reaction mixture was filtered
5. 5
   浓缩The filtrate was concentrated
6. 6
   温度cooled in an ice bath, in the course of which a solid
7. 7
   其他precipitated out
8. 8
   其他This was removed by means of a blue-band filter
9. 9
   其他dried
10. 10
    其他The crude product (23.22 g) was recrystallized from 70 ml of ethanol
11. 11
    其他an m.p. of 61-62° C. (lit. 62° C.)
12. 12
    其他were obtained

实验过程

A reaction mixture composed of 21.40 g (95.3 mmol) of 98% 4-iodophenol, 12.19 g (95.3 mmol) of 99% benzyl chloride, 20.73 g (150 mmol) of potassium carbonate and 250 ml of acetone was heated to reflux temperature and heated to boiling for 30 hours. After cooling to room temperature, the reaction mixture was filtered. The filtrate was concentrated and then cooled in an ice bath, in the course of which a solid precipitated out. This was removed by means of a blue-band filter and then dried. The crude product (23.22 g) was recrystallized from 70 ml of ethanol. 17.20 g (58% of theory) of colorless microcrystals having an m.p. of 61-62° C. (lit. 62° C.) were obtained.

来源