反应 #172545

反应方程式

2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoic acid

ethyl 2-hydroxybenzoate

DCC

→

ethyl 2-(2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoyloxy)benzoate

收率 67.0%

溶剂

CH3CN THF

反应条件

后处理

1. 1
   过滤filtered
2. 2
   浓缩concentrated under reduced pressure
3. 3
   其他The crude product was purified by silica gel chromatography (EtOAc-PE, 0-20%)

实验过程

To a solution of 2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoic acid (50 mg, 0.11 mmol) and ethyl 2-hydroxybenzoate (19 mg, 0.11 mmol) in CH3CN/THF (1:1, 0.5 mL) at −10° C. was added DCC (12 mg, 0.11 mmol) and DMAP (1 mg). The mixture was stirred (RT, 16 h), filtered and concentrated under reduced pressure. The crude product was purified by silica gel chromatography (EtOAc-PE, 0-20%) to afford ethyl 2-(2-docosa-4,7,10,13,16,19-hexaenamido-4-methylpentanoyloxy)benzoate (40 mg, 67%) as colorless oil. Mass calculated for C37H51NO5=589.80; found: [M+H]+=590.4.

来源